Synergistic effect of antibodies to human leukocyte antigens and defensins in pathogenesis of bronchiolitis obliterans syndrome after human lung transplantation
نویسندگان
چکیده
منابع مشابه
Bronchiolitis Obliterans After Lung Transplantation
ing lung transplantation is 71%, and 46% of trans¬ plant recipients will survive at least 5 years.1 Al¬ though infections, medication-related adverse events, and malignancies remain important compli¬ cations, prolonged survival is limited predominantly by bronchiolitis obliterans (RO), a condition that was associated with transplantation more than a decade ago.25 Data suggest that at least 50% ...
متن کاملMatrix metalloproteinase-9 in bronchiolitis obliterans syndrome after lung transplantation.
Bronchiolitis obliterans syndrome (BOS) is a severe complication after lung transplantation (LTX). In a retrospective cohort study 12 stable healthy recipients (non-BOS) and eight patients with BOS were enrolled after LTX and matrix metalloproteinases (MMP)-9, TIMP-1 and cell characteristics in bronchoalveolar lavage (BAL) samples (n = 145) were analysed. BALs from patients with BOS were furthe...
متن کاملDe novo donor HLA-specific antibodies predict development of bronchiolitis obliterans syndrome after lung transplantation.
BACKGROUND Bronchiolitis obliterans syndrome (BOS) is the major cause of late graft failure after lung transplantation. The objective was to determine whether de novo donor human leukocyte antigen (HLA)-specific antibodies (DSA) are associated with the development of BOS or patient survival. Data were analyzed from 188 lung transplant recipients with a follow-up period up to 8 years. METHODS ...
متن کاملBronchiolitis obliterans following lung transplantation.
Bronchiolitis obliterans syndrome (BOS) is the main and late chronic complication after lung transplantation. It remains a major impediment to long-term outcome. Unfortunately, the survival rate of lung transplant recipients lags behind that of other organ transplant recipients, and BOS accounts for more than 30% of all mortality after the third year following lung transplantation. Most recent ...
متن کاملBronchiolitis obliterans syndrome and additional costs of lung transplantation.
STUDY OBJECTIVES The influence of bronchiolitis obliterans syndrome (BOS) on costs after lung transplantation was investigated by comparing the costs of patients with and without this condition. DESIGN Follow-up costs were prospectively investigated in a medical technology assessment of the Dutch Lung Transplant Program, in relation to the development of the BOS. First, average follow-up cost...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2010
ISSN: 1053-2498
DOI: 10.1016/j.healun.2010.05.036